Mårin P, Lönn L, Andersson B, Odén B, Olbe L, Bengtsson B A, Björntorp P
Department of Heart and Lung Diseases, Sahlgren's Hospital, University of Goteborg, Sweden.
J Clin Endocrinol Metab. 1996 Mar;81(3):1018-22. doi: 10.1210/jcem.81.3.8772568.
To determine the effects of testosterone (T) on lipid assimilation in different adipose tissue depots, T (250 mg, im) was given to 17 middle-aged men 5 days before abdominal surgery. Twenty-four hours before surgery, 10 microCi labeled oleic acid in 80 g milk fat were administered orally. Lipid radioactivity was measured in adipose tissue biopsies from abdominal ac, omental, and retroperitoneal adipose tissues. Subcutaneous, visceral (omental plus mesenteric), and retroperitoneal adipose tissue masses were determined using computerized tomography scans at 22 levels. Sixteen men who were not treated with T served as controls. T administration was followed by an increase in serum concentrations from 17.7 +/- 1.1 to 32.6 +/- 1.8 nmol/L (P < 0.001) and a marked (> 50%) reduction compared with controls in lipid radioactivity in omental and retroperitoneal adipose tissues, but not in sc adipose tissue. In controls, sc, visceral, and retroperitoneal adipose tissues assimilated 59.2 g (73.4%), 16.9 g (20.9%), and 4.6 g (5.7%), respectively, of the orally administered fat. In the T-treated men, this was changed to 73.5 g (88.8%), 6.4 g (7.7%), and 2.9 g (3.5%), respectively. It was concluded that T inhibits triglyceride assimilation in intra-abdominal depots and apparently directs this lipid to sc fat in men.
为确定睾酮（T）对不同脂肪组织储存库中脂质同化的影响，在腹部手术前5天，给17名中年男性注射T（250mg，肌肉注射）。手术前24小时，口服含10微居里标记油酸的80g乳脂肪。测定腹部皮下、网膜和腹膜后脂肪组织活检中的脂质放射性。使用计算机断层扫描在22个层面测定皮下、内脏（网膜加肠系膜）和腹膜后脂肪组织质量。16名未接受T治疗的男性作为对照。注射T后，血清浓度从17.7±1.1nmol/L增至32.6±1.8nmol/L（P<0.001），网膜和腹膜后脂肪组织中的脂质放射性与对照组相比显著降低（>50%），但皮下脂肪组织未降低。在对照组中，皮下、内脏和腹膜后脂肪组织分别吸收了口服脂肪的59.2g（73.4%）、16.9g（20.9%）和4.6g（5.7%）。在接受T治疗的男性中，这一比例分别变为73.5g（88.8%）、6.4g（7.7%）和2.9g（3.5%）。得出的结论是，T抑制男性腹内脂肪储存库中的甘油三酯同化，并显然将这种脂质导向皮下脂肪。
