环丙沙星对HT - 29人结肠癌细胞系的体外作用：通过胸腺嘧啶核苷摄取和银染核仁组成区（AgNOR）组织形态计量学评估细胞增殖。
In vitro effect of ciprofloxacin on HT-29 human colon carcinoma cell line: assessment of cell proliferation by thymidine uptake and silver nucleolar organizer regions (AgNOR) histomorphometry.
作者信息
Rabau M, Nyska A, Dayan D
机构信息
Department of Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
出版信息
Arch Toxicol. 1995;70(2):124-6. doi: 10.1007/BF02733673.
In an in vitro study, the effect of ciprofloxacin was examined on proliferation of HT-29 human colon carcinoma cell line. Cell proliferation was measured by 3H-thymidine uptake and silver nucleolar organizer region (AgNOR) histomorphometry. A significant increase in [3H]thymidine incorporation (p < 0.05) parallel with a significant increase in the mean AgNOR clusters/cells (p < 0.01) was noted after 5 days of cell exposure to ciprofloxacin. It is suggested that the assessment of AgNOR variables is useful in examination of quinolone effect on HT-29 human colon carcinoma cell proliferation.
在一项体外研究中，检测了环丙沙星对HT - 29人结肠癌细胞系增殖的影响。通过³H - 胸腺嘧啶核苷摄取和银染核仁组成区（AgNOR）组织形态计量学来测量细胞增殖。在细胞暴露于环丙沙星5天后，观察到[³H]胸腺嘧啶核苷掺入显著增加（p < 0.05），同时平均AgNOR簇/细胞显著增加（p < 0.01）。提示AgNOR变量评估在检测喹诺酮对HT - 29人结肠癌细胞增殖的作用方面是有用的。
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