环丙沙星对丝裂原刺激的淋巴细胞增殖的影响。
Effect of ciprofloxacin on mitogen-stimulated lymphocyte proliferation.
作者信息
Gollapudi S V, Prabhala R H, Thadepalli H
出版信息
Antimicrob Agents Chemother. 1986 Feb;29(2):337-8. doi: 10.1128/AAC.29.2.337.
Abstract
Ciprofloxacin was tested for its inhibitory or stimulatory effects on concanavalin A- and phytohemagglutinin-stimulated proliferation (measured by [3H]thymidine uptake) of human peripheral blood mononuclear cells and murine splenocytes. Ciprofloxacin did not diminish or enhance mononuclear cell proliferation at concentrations of 5 to 125 micrograms/ml. Further, the proliferative response of splenocytes of mice previously treated with ciprofloxacin (40 mg/kg, twice daily for 5 days) was essentially similar to that of untreated controls.
摘要
对环丙沙星进行了测试，观察其对人外周血单核细胞和小鼠脾细胞在伴刀豆球蛋白A和植物血凝素刺激下增殖（通过[3H]胸腺嘧啶核苷摄取来测定）的抑制或刺激作用。在浓度为5至125微克/毫升时，环丙沙星不会减少或增强单核细胞的增殖。此外，先前用环丙沙星（40毫克/千克，每日两次，共5天）处理过的小鼠脾细胞的增殖反应与未处理的对照组基本相似。
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