环丙沙星对丝裂原刺激的淋巴细胞增殖的影响。
Effect of ciprofloxacin on mitogen-stimulated lymphocyte proliferation.
作者信息
Gollapudi S V, Prabhala R H, Thadepalli H
出版信息
Antimicrob Agents Chemother. 1986 Feb;29(2):337-8. doi: 10.1128/AAC.29.2.337.
Abstract
Ciprofloxacin was tested for its inhibitory or stimulatory effects on concanavalin A- and phytohemagglutinin-stimulated proliferation (measured by [3H]thymidine uptake) of human peripheral blood mononuclear cells and murine splenocytes. Ciprofloxacin did not diminish or enhance mononuclear cell proliferation at concentrations of 5 to 125 micrograms/ml. Further, the proliferative response of splenocytes of mice previously treated with ciprofloxacin (40 mg/kg, twice daily for 5 days) was essentially similar to that of untreated controls.
摘要
对环丙沙星进行了测试，观察其对人外周血单核细胞和小鼠脾细胞在伴刀豆球蛋白A和植物血凝素刺激下增殖（通过[3H]胸腺嘧啶核苷摄取来测定）的抑制或刺激作用。在浓度为5至125微克/毫升时，环丙沙星不会减少或增强单核细胞的增殖。此外，先前用环丙沙星（40毫克/千克，每日两次，共5天）处理过的小鼠脾细胞的增殖反应与未处理的对照组基本相似。
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本文引用的文献
1
Effect of antibiotics on the immune response.抗生素对免疫反应的影响。
Am J Med. 1982 May;72(5):711-6. doi: 10.1016/0002-9343(82)90534-4.
2
A novel mitogen released by lipid A-stimulated bone marrow cells.
J Immunol. 1982 May;128(5):2206-8.
3
Nonresponsiveness of immature B lymphocytes to anti-immunoglobulin is reversed by pronase.
Biochem Biophys Res Commun. 1984 Feb 29;119(1):1-5. doi: 10.1016/0006-291x(84)91609-7.
4
Quinolone antibiotics inhibit eucaryotic DNA polymerase alpha and beta, terminal deoxynucleotidyl transferase but not DNA ligase.喹诺酮类抗生素可抑制真核生物DNA聚合酶α和β、末端脱氧核苷酸转移酶，但不抑制DNA连接酶。
Biochem Biophys Res Commun. 1984 Jun 29;121(3):762-9. doi: 10.1016/0006-291x(84)90744-7.
5
Effects of moxalactam and cefuroxime on mitogen-stimulated human mononuclear leukocytes.羟羧氧酰胺菌素和头孢呋辛对有丝分裂原刺激的人单核白细胞的作用。
Antimicrob Agents Chemother. 1983 Mar;23(3):360-3. doi: 10.1128/AAC.23.3.360.
6
In vitro effects of doxycycline and tetracycline on mitogen stimulated lymphocyte growth.强力霉素和四环素对丝裂原刺激的淋巴细胞生长的体外作用。
Clin Exp Immunol. 1983 Aug;53(2):458-64.
7
Simplified, accurate method for antibiotic assay of clinical specimens.临床标本抗生素检测的简化、准确方法。
Appl Microbiol. 1966 Mar;14(2):170-7. doi: 10.1128/am.14.2.170-177.1966.
8
Inhibition of mitogen-induced human lymphocyte proliferative responses by tetracycline analogues.四环素类似物对丝裂原诱导的人淋巴细胞增殖反应的抑制作用。
Clin Exp Immunol. 1979 Mar;35(3):443-6.
9
Antibiotics and suppression of lymphocyte function in vitro.抗生素与体外淋巴细胞功能的抑制
Antimicrob Agents Chemother. 1979 Nov;16(5):554-60. doi: 10.1128/AAC.16.5.554.
10
Suppression of lymphocyte responses by cephalosporins.头孢菌素对淋巴细胞反应的抑制作用。
Infect Immun. 1978 Feb;19(2):378-84. doi: 10.1128/iai.19.2.378-384.1978.
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