喹诺酮类药物会影响胸苷掺入人淋巴细胞的DNA中。
Quinolones affect thymidine incorporation into the DNA of human lymphocytes.
作者信息
Forsgren A, Bergh A K, Brandt M, Hansson G
出版信息
Antimicrob Agents Chemother. 1986 Mar;29(3):506-8. doi: 10.1128/AAC.29.3.506.
Abstract
The incorporation of [3H]thymidine into DNA was increased in phytohemagglutinin-stimulated human lymphocytes exposed to four of the new quinolone derivatives (ciprofloxacin, norfloxacin, ofloxacin, and A 56620) at concentrations achievable in clinical situations. However, proliferation of phytohemagglutinin-stimulated lymphocytes was not influenced by ciprofloxacin at concentrations of 0.5 to 10 micrograms/ml.
摘要
在临床可达到的浓度下，将四种新喹诺酮衍生物（环丙沙星、诺氟沙星、氧氟沙星和A 56620）作用于经植物血凝素刺激的人淋巴细胞，[3H]胸苷掺入DNA的量增加。然而，在浓度为0.5至10微克/毫升时，环丙沙星对经植物血凝素刺激的淋巴细胞增殖没有影响。
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