Müller R, Koller B, Hildebrand T, Laib A, Gianolini S, Rüegsegger P
Institute for Biomedical Engineering, University of Zürich, Switzerland.
Technol Health Care. 1996 Apr;4(1):113-9.
Micro-computed tomography (microCT) is an emerging technique for the non-destructive assessment and analysis of the three-dimensional cancellous bone architecture. However, the procedures the procedures and applications used to quantify bone structures are not yet standardized. The aim of this study was to provide more insight in the resolution-dependency of microstructural properties of three-dimensional trabecular bone. Ten iliac crest bone biopsies were measured using a newly devised microCT system providing a nominal isotropic resolution of 14 microns. To study the resolution dependency the measured data were reconstructed on reduced image arrays with reduction factors ranging from 2 to 20. To assess the structural properties, morphometric parameters were computed based on a truly three-dimensional approach. The results showed a strong resolution dependency of the structural properties and that, if very precise results are needed, only the highest resolution will predict the correct values. Nevertheless, since the properties either decrease or increase monotonously up to a nominal resolution of about 175 microns, the values appear to be restorable using a suitable calibration procedure.
微计算机断层扫描（microCT）是一种用于对三维松质骨结构进行无损评估和分析的新兴技术。然而，用于量化骨结构的程序和应用尚未标准化。本研究的目的是更深入地了解三维小梁骨微观结构特性的分辨率依赖性。使用新设计的微CT系统对10例髂嵴骨活检样本进行测量，该系统的标称各向同性分辨率为14微米。为了研究分辨率依赖性，将测量数据在缩减因子范围为2至20的缩减图像阵列上进行重建。为了评估结构特性，基于真正的三维方法计算形态计量学参数。结果表明，结构特性对分辨率有很强的依赖性，并且，如果需要非常精确的结果，只有最高分辨率才能预测正确的值。然而，由于这些特性在高达约175微米的标称分辨率之前要么单调下降要么单调增加，因此使用合适的校准程序似乎可以恢复这些值。
