Kusukawa J, Harada H, Shima I, Sasaguri Y, Kameyama T, Morimatsu M
Department of Oral and Maxillofacial Surgery, Kurume University School of Medicine, Japan.
Eur J Cancer B Oral Oncol. 1996 Jul;32B(4):217-21. doi: 10.1016/0964-1955(96)00016-4.
Surgical specimens from 65 patients with squamous cell carcinoma (SCC) of the oral cavity were examined immunohistochemically. The clinicopathological significance of the expression of epidermal growth factor receptor (EGFR) and matrix metalloproteinase-3 (MMP-3) was assessed. Among the 65 tumours, 20(30.8%) and 37(56.9%) tested positively for EGFR and MMP-3, respectively. A positive correlation between the expression of EGFR and MMP-3 was found. The expression of EGFR in oral SCCs was associated with an advanced T stage of the primary tumour, an advanced pathological stage, and a high incidence of neck metastasis. In addition, MMP-3 was primarily expressed at the advancing front of cancer with a diffuse invasive mode. Thus, overexpression of MMP-3 was associated with an advanced pathological stage, a diffuse invasive mode, and a high incidence of neck metastasis. The analysis of MMP-3 expression is useful to evaluate the pathological status of tumours. Because EGFR-overexpressed tumour should produce larger amounts of MMP-3 in vivo, a close examination of oral SCC for expression of EGFR and MMP-3 should be helpful to predict their malignant potential.
对65例口腔鳞状细胞癌（SCC）患者的手术标本进行免疫组化检查。评估表皮生长因子受体（EGFR）和基质金属蛋白酶-3（MMP-3）表达的临床病理意义。在65例肿瘤中，EGFR和MMP-3检测呈阳性的分别有20例（30.8%）和37例（56.9%）。发现EGFR和MMP-3的表达之间存在正相关。口腔SCC中EGFR的表达与原发肿瘤的T分期晚期、病理分期晚期以及颈部转移的高发生率相关。此外，MMP-3主要在具有弥漫浸润模式的癌前沿表达。因此，MMP-3的过表达与病理分期晚期、弥漫浸润模式以及颈部转移的高发生率相关。MMP-3表达分析有助于评估肿瘤的病理状态。由于EGFR过表达的肿瘤在体内应产生大量MMP-3，因此密切检查口腔SCC中EGFR和MMP-3的表达应有助于预测其恶性潜能。
