Koffler M, Kisch E S
Diabetes Unit, Tel-Aviv University Medical Center, Ichilov Hospital, Israel.
J Diabetes Complications. 1996 Mar-Apr;10(2):109-12. doi: 10.1016/1056-8727(94)00077-8.
We have observed seven initially obese individuals who, during the course of a strenuous weight-reduction program, developed diabetes mellitus: non-insulin-dependent diabetes mellitus in five cases and insulin-dependent diabetes mellitus in two cases. None had any sign of prior diabetic symptoms. Although weight reduction is encouraged in obesity, crash diets without proper medical surveillance may have deleterious effects. This sequence of induction of diabetes has not previously been reported in the medical literature. The metabolic situation in extremely low-calorie diets may be comparable to that in starvation. An attempt is made to explain our observation concerning the induction of a diabetic state during such diets, on the basis of increased insulin resistance in states of starvation and anorexia nervosa, with a concomitant role in stress hormones.
我们观察到7名最初肥胖的个体，在剧烈的减肥计划过程中患上了糖尿病：5例为非胰岛素依赖型糖尿病，2例为胰岛素依赖型糖尿病。他们之前均无任何糖尿病症状迹象。虽然肥胖时鼓励减肥，但没有适当医学监测的速成节食可能会产生有害影响。这种糖尿病诱发序列此前在医学文献中尚未有报道。极低热量饮食时的代谢状况可能与饥饿时相当。我们试图基于饥饿和神经性厌食状态下胰岛素抵抗增加以及应激激素的协同作用，来解释我们关于此类饮食期间诱发糖尿病状态的观察结果。
