Cell Stress Biology, Roswell Park Cancer Institute , Buffalo , NY , USA.
Cell Cycle. 2019 Sep;18(18):2157-2163. doi: 10.1080/15384101.2019.1644765. Epub 2019 Aug 1.
Designed a century ago to treat epilepsy, the ketogenic diet (KD) is also effective against obesity and diabetes. Paradoxically, some studies in rodents have found that the KD seemingly causes diabetes, contradicting solid clinical data in humans. This paradox can be resolved by applying the concept of starvation pseudo-diabetes, which was discovered in starved animals almost two centuries ago, and has also been observed in some rapamycin-treated rodents. Intriguingly, use of the KD and rapamycin is indicated for a similar spectrum of diseases, including Alzheimer's disease and cancer. Even more intriguingly, benevolent (starvation) pseudo-diabetes may counteract type 2 diabetes or its complications.
一个世纪前设计用于治疗癫痫的生酮饮食（KD）对肥胖和糖尿病也有效。矛盾的是，一些啮齿动物的研究发现，KD 似乎会导致糖尿病，与人类的可靠临床数据相矛盾。这个悖论可以通过应用饥饿性假性糖尿病的概念来解决，这个概念在近两个世纪前的饥饿动物中被发现，并且在一些接受雷帕霉素治疗的啮齿动物中也有观察到。有趣的是，KD 和雷帕霉素的使用表明它们对包括阿尔茨海默病和癌症在内的类似疾病谱有疗效。更有趣的是，仁慈的（饥饿）假性糖尿病可能对抗 2 型糖尿病或其并发症。
