Cepollaro C, Orlandi G, Gonnelli S, Ferrucci G, Arditti J C, Borracelli D, Toti E, Gennari C
Institute of Internal Medicine, University of Siena, Nuovo Policlinico Viale Bracci 53100 Siena, Italy.
Calcif Tissue Int. 1996 Oct;59(4):238-9. doi: 10.1007/s002239900115.
It is generally agreed that an adequate calcium intake is necessary for the maintenance of bone health and that calcium supplementation reduces the rate of bone loss in postmenopausal women. Mineral waters are calorie free, and some, with relatively high calcium levels, might be significant sources of calcium. We studied the effect of mineral water in 45 early postmenopausal women randomly assigned to receive a high-calcium (Ferrarelle, Italy) or a low-calcium mineral water. On the basis of the dietary regimen, women were divided in two clusters (A = 23 subjects, B = 22 subjects) significantly different only for calcium intake (CI) and for dietary consumption of calories (energy). At the end of the study period (13 +/- 1 months), bone mineral density at the distal radius showed a significant decrease (P < 0.001) only in cluster with low CI. The difference between the clusters was significant (P < 0.05). Furthermore, the cluster with high CI showed a significant (P < 0.05) reduction in osteocalcin serum levels after 3 months. This study provides further evidence to support the use of a high calcium mineral water as an effective prophylaxis against postmenopausal bone loss.
人们普遍认为，充足的钙摄入量对于维持骨骼健康是必要的，并且补充钙可以降低绝经后女性的骨质流失率。矿泉水不含热量，一些钙含量相对较高的矿泉水可能是重要的钙来源。我们对45名绝经早期女性进行了研究，她们被随机分配饮用高钙矿泉水（意大利费拉雷洛）或低钙矿泉水。根据饮食方案，女性被分为两组（A组 = 23名受试者，B组 = 22名受试者），两组仅在钙摄入量（CI）和热量饮食消耗方面有显著差异。在研究期结束时（13 ± 1个月），仅低CI组的桡骨远端骨密度出现显著下降（P < 0.001）。两组之间的差异显著（P < 0.05）。此外，高CI组在3个月后血清骨钙素水平显著降低（P < 0.05）。这项研究提供了进一步的证据，支持使用高钙矿泉水作为预防绝经后骨质流失的有效措施。
