Kalpaklioğlu A F, Ferizli A G, Misirligil Z, Demirel Y S, Gürbüz L
Faculty of Medicine, Department of Allergic Diseases, University of Ankara, Turkey.
Allergy. 1996 Mar;51(3):164-70. doi: 10.1111/j.1398-9995.1996.tb04581.x.
Several observations have indicated that house-dust mites (HDM) play an important role in allergic diseases. Thus, the primary form of treatment should aim at reducing exposure to HDM for these patients. Allergen-avoidance measures in homes have been demonstrated to be beneficial in decreasing the risk of sensitization, severity of symptoms, bronchial reactivity, and basophil sensitivity. Various chemical methods, as well as physical measures, have been tried to eliminate mite allergens from house dust. However, none have gained wide acceptance because of the lack of effectiveness and safety, and the high cost. It is clear that new approaches are required for effective long-term control of HDM allergens. This study compared the acaricidal activities of phenyl salicylate, tea leaf extract (high tannic acid content), and essential oils (eucalyptus and laurel) with that of benzyl benzoate. The contact, short-duration persistence, and residual effects of various concentrations of these chemicals and benzyl benzoate were assessed in laboratory conditions with specially designed wells. Our data suggest that benzyl benzoate may not be effective when applied according to the manufacturer's instructions, but may be effective when applied more frequently (i.e., three to four times a year) and for longer periods (up to 24 h) even with lower concentrations (0.4%). Essential oils were shown to have little acaricidal activity, but virtually no effect was observed with tea. Among the chemicals used, phenyl salicylate seems to be promising as an alternative acaricide.
多项观察表明，屋尘螨（HDM）在过敏性疾病中起重要作用。因此，对于这些患者，主要的治疗形式应旨在减少与屋尘螨的接触。已证明家庭中的过敏原回避措施有利于降低致敏风险、症状严重程度、支气管反应性和嗜碱性粒细胞敏感性。人们尝试了各种化学方法以及物理措施来清除屋尘中的螨过敏原。然而，由于缺乏有效性、安全性以及成本高昂，这些方法都未得到广泛认可。显然，需要新的方法来有效长期控制屋尘螨过敏原。本研究比较了水杨酸苯酯、茶叶提取物（高单宁酸含量）和精油（桉树和月桂）与苯甲酸苄酯的杀螨活性。在实验室条件下，使用专门设计的孔板评估了这些化学物质和苯甲酸苄酯不同浓度的接触、短期持久性和残留效果。我们的数据表明，按照制造商的说明使用时，苯甲酸苄酯可能无效，但即使使用较低浓度（0.4%），更频繁地（即每年三到四次）和更长时间地（长达24小时）使用时可能有效。精油显示出几乎没有杀螨活性，但茶叶几乎没有观察到效果。在所使用的化学物质中，水杨酸苯酯似乎是一种有前景的替代杀螨剂。
