Hart B J, Guérin B, Nolard N
Royal Agricultural College, Cirencester, Gloucestershire, U.K.
Clin Exp Allergy. 1992 Oct;22(10):923-8. doi: 10.1111/j.1365-2222.1992.tb02065.x.
The acaricidal and fungicidal activities of a new acaricide Allerbiocid, formulated for the control of house dust mites, were investigated. The components of the Allerbiocid formula are: 3% benzyl benzoate (acaricidal and fungicidal), 1% tannic acid (protein denaturant) and 0.5% Tween (surface active agent) in 70% isopropyl alcohol (antiseptic). At application rates of both 150 and 250 ml/m2, the acaricidal activity appeared to work by both ingestion and contact and remained active upon contact with mites for up to 10 weeks. When Sabouraud agar was treated with Allerbiocid at a concentration of 5 ml/20 ml medium, the preparation was also found to have fungicidal and fungistatic activities on various species of fungi commonly found in house dust. Allerbiocid contains tannic acid which is a protein denaturant. Levels of Der p I in dust were found to be reduced by over 90% after treatment with Allerbiocid. The importance of denaturation of mite faecal allergens and allergens associated with dead fungal spores is discussed.
对一种新的杀螨剂Allerbiocid进行了研究，该杀螨剂专为控制屋尘螨而配制。Allerbiocid配方的成分包括：70%异丙醇（防腐剂）中的3%苯甲酸苄酯（杀螨和杀真菌剂）、1%单宁酸（蛋白质变性剂）和0.5%吐温（表面活性剂）。在150和250毫升/平方米的施用量下，杀螨活性似乎通过摄入和接触起作用，与螨虫接触后长达10周仍保持活性。当用浓度为5毫升/20毫升培养基的Allerbiocid处理沙堡琼脂时，还发现该制剂对屋尘中常见的各种真菌具有杀真菌和抑菌活性。Allerbiocid含有作为蛋白质变性剂的单宁酸。用Allerbiocid处理后，发现灰尘中Der p I的水平降低了90%以上。讨论了螨类粪便过敏原和与死真菌孢子相关的过敏原变性的重要性。
