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具有CD4阻断和抗1型人类免疫缺陷病毒活性的萘磺酸盐聚合物。

Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities.

作者信息

Rusconi S, Moonis M, Merrill D P, Pallai P V, Neidhardt E A, Singh S K, Willis K J, Osburne M S, Profy A T, Jenson J C, Hirsch M S

机构信息

Infectious Disease Unit, Massachusetts General Hospital, Boston 02114, USA.

出版信息

Antimicrob Agents Chemother. 1996 Jan;40(1):234-6. doi: 10.1128/AAC.40.1.234.

DOI:10.1128/AAC.40.1.234
PMID:8787913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163090/
Abstract

PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.

摘要

PIC 024 - 4和PRO 2000是萘磺酸盐聚合物，它们以纳摩尔亲和力与CD4结合并阻断gp120的结合。二者在H9细胞、外周血单核细胞和原代单核细胞/巨噬细胞中均具有抗1型人类免疫缺陷病毒的活性，与齐多夫定具有协同作用，并且在抗1型人类免疫缺陷病毒浓度下不抑制破伤风类毒素刺激的T细胞增殖。

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