Knüppel R, Dietze P, Lehnberg W, Frech K, Wingender E
Gesellschaft für Biotechnologische Forschung, Department of Genetics, Braunschweig, Germany.
J Comput Biol. 1994 Fall;1(3):191-8. doi: 10.1089/cmb.1994.1.191.
DNA sequences that are involved in the control of gene expression in eukaryotes have been collected in conjunction with the proteins binding to and acting through them (TRANSFAC data set). To make these data accessible, the TRANSFAC retrieval program (TRP) has been developed as a database management system which is based upon the network model. This database model possesses particular advantages for data management of a complex structure. The aim of TRP is to provide an easily handled statistical basis for a computational approach to transcription control.
真核生物中参与基因表达调控的DNA序列已与与之结合并通过它们起作用的蛋白质一起收集（TRANSFAC数据集）。为了便于获取这些数据，已经开发了TRANSFAC检索程序（TRP）作为基于网络模型的数据库管理系统。这种数据库模型在复杂结构的数据管理方面具有特殊优势。TRP的目的是为转录调控的计算方法提供一个易于处理的统计基础。
