Elliott C T, Shortt H D, Kennedy D G, McCaughey W J
Residue Laboratory, Veterinary Sciences Division, Stormont, Belfast.
Vet Q. 1996 Jun;18(2):41-4. doi: 10.1080/01652176.1996.9694612.
Laboratory testing in N. Ireland for the illegal growth promoting agent, clenbuterol (CBL), is centralized at the Veterinary Sciences Division, Belfast. During the past 6 years a variety of testing schemes have evolved to determine the level of abuse of this drug in the local meat industry. The types of samples from cattle tested during this period altered as pharmacokinetic data for the compound increased. Initially, fluids such as urine and bile were used, however testing switched to more appropriate tissues such as liver, eyes, and hair. The first positive samples were detected in 1990, with 43 out of 121 samples tested showing detectable residues. In the following year, this number increased to 139 out of 286 tests. Despite substantial increases in the number of samples analysed over the succeeding years, the numbers of positive results steadily declined, thus giving strong evidence that abuse was also on the decline. From the data collected over the 6-year period, it became clear that the EU National Surveillance Scheme designed to detect abuse of illegal substances was ineffective and locally designed programmes were required to effectively tackle the problem.
北爱尔兰针对非法促生长剂克伦特罗（CBL）的实验室检测集中在贝尔法斯特的兽医科学部进行。在过去6年里，为确定这种药物在当地肉类行业的滥用程度，已逐步形成了多种检测方案。随着该化合物药代动力学数据的增加，在此期间检测的牛的样本类型也发生了变化。最初使用尿液和胆汁等液体进行检测，然而后来检测转向了更合适的组织，如肝脏、眼睛和毛发。1990年首次检测到阳性样本，在检测的121个样本中有43个显示出可检测到的残留物。次年，在286次检测中有139个呈阳性。尽管在随后几年中分析的样本数量大幅增加，但阳性结果的数量却稳步下降，因此有力地证明了滥用情况也在减少。从6年期间收集的数据来看，很明显欧盟旨在检测非法物质滥用情况的国家监测计划并不有效，需要制定本地计划来有效解决这一问题。
