López-Carrillo L, Torres-Arreola L, Torres-Sánchez L, Espinosa-Torres F, Jiménez C, Cebrián M, Waliszewski S, Saldate O
National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Environ Health Perspect. 1996 Jun;104(6):584-8. doi: 10.1289/ehp.104-1469381.
We review the potential impact of DDT on public health in Mexico. DDT production and consumption patterns in Mexico during the last 20 years are described and compared with those in the United States. In spite of the restrictions on DDT use in antimalaria campaigns in Mexico, use of DDT is still higher than in other Latin American countries. We analyzed information from published studies to determine accumulated levels of this insecticide in blood, adipose tissue, and breast milk samples from Mexican women. Current lipid-adjusted DDE levels from women living in Mexico City are 6.66 ppb in mammary adipose tissue and 0.594 ppm in total breast milk. Finally, the methodological limitations of existing epidemiological studies on DDT exposure and breast cancer are discussed. We conclude that DDT use in Mexico is a public health problem, and suggest two solutions: identification of alternatives for the control of malaria and educational intervention to reduce DDT exposure. We also recommend strengthening epidemiological studies to evaluate the association between accumulated DDT levels in adipose tissue and breast cancer incidence among Mexican women.
我们回顾了滴滴涕对墨西哥公众健康的潜在影响。描述了墨西哥过去20年中滴滴涕的生产和消费模式，并与美国的情况进行了比较。尽管墨西哥在抗疟运动中对滴滴涕的使用有所限制，但滴滴涕的使用量仍高于其他拉丁美洲国家。我们分析了已发表研究中的信息，以确定墨西哥女性血液、脂肪组织和母乳样本中这种杀虫剂的累积水平。居住在墨西哥城的女性目前经脂质调整后的滴滴涕代谢物（DDE）水平在乳腺脂肪组织中为6.66 ppb，在全脂母乳中为0.594 ppm。最后，讨论了现有关于滴滴涕暴露与乳腺癌的流行病学研究的方法学局限性。我们得出结论，在墨西哥使用滴滴涕是一个公共卫生问题，并提出了两种解决方案：确定控制疟疾的替代方法以及开展教育干预以减少滴滴涕暴露。我们还建议加强流行病学研究，以评估墨西哥女性脂肪组织中滴滴涕的累积水平与乳腺癌发病率之间的关联。
