Murrer L H, Marijnissen J P, Star W M
Department of Clinical Physics, Dr Daniel Den Hoed Cancer Centre, Erasmus University Hospital, Rotterdam, The Netherlands.
Phys Med Biol. 1996 Jun;41(6):951-61. doi: 10.1088/0031-9155/41/6/001.
The distribution of the light emitted by linear light diffusers commonly employed in photodynamic therapy (PDT) has been investigated. A device is presented which measures the angular distribution of the exiting light at each point of the diffuser. With these data the fluence rate in air or in a cavity at some distance from the diffuser can be predicted. The results show that the light is scattered from the diffuser predominantly in the forward direction. Experiments and calculations show that the fluence rate in air and in a cavity of scattering tissue at some distance from the diffuser has a maximum near the tip of the diffuser, instead of near the middle. However, the fluence rate resulting from an interstitial diffuser in a purely scattering tissue phantom shows a maximum in the bisecting plane of the diffuser as would be predicted when the diffuser emitted light isotropically. The scattering nature of the tissue is expected to cancel the anisotropy of the diffuser.
对光动力疗法（PDT）中常用的线性光扩散器发出的光的分布进行了研究。介绍了一种装置，该装置可测量扩散器各点出射光的角分布。利用这些数据，可以预测在距扩散器一定距离处的空气中或腔体内的注量率。结果表明，光主要从扩散器向前散射。实验和计算表明，在距扩散器一定距离处的空气中和散射组织腔体内的注量率在扩散器尖端附近有最大值，而不是在中间附近。然而，在纯散射组织模型中，间质扩散器产生的注量率在扩散器的平分面上显示出最大值，这与扩散器各向同性发光时的预测结果一致。预计组织的散射特性会抵消扩散器的各向异性。
