Katz-Salamon M, Eriksson M, Jónsson B
Department of Women's and Child Health, Karolinska Hospital, Stockholm, Sweden.
Arch Dis Child Fetal Neonatal Ed. 1996 Jul;75(1):F4-9. doi: 10.1136/fn.75.1.f4.
Ten preterm infants with chronic lung disease (CLD) and undeveloped peripheral chemoreceptor function, described as ventilatory response to hyperoxia, were investigated, according to an individual protocol. Each infant was followed up until the response to hyperoxic inhalation had been observed on two occasions. Each examination consisted of overnight recording of saturation, testing of lung compliance and airway resistance, and the hyperoxic test. The hyperoxic response appeared at a mean postnatal age of 14 weeks (range 9-33 weeks). This response, which was independent of the infant's lung mechanics, appeared much later in infants with the severe form of CLD. As undeveloped peripheral chemoreceptor function has been suggested to be a key factor in sudden infant death syndrome (SIDS), the delayed development of their chemosensitivity leaves some infants with CLD unprotected against hypoxia at the age at which the risk for SIDS is highest.
根据个体方案，对10名患有慢性肺病（CLD）且外周化学感受器功能未发育的早产儿进行了研究，其外周化学感受器功能通过对高氧的通气反应来描述。对每名婴儿进行随访，直至观察到两次高氧吸入反应。每次检查包括夜间饱和度记录、肺顺应性和气道阻力测试以及高氧试验。高氧反应出现在出生后平均14周（范围9 - 33周）。这种反应与婴儿的肺力学无关，在患有严重CLD的婴儿中出现得要晚得多。由于外周化学感受器功能未发育被认为是婴儿猝死综合征（SIDS）的关键因素，其化学敏感性发育延迟使一些CLD婴儿在SIDS风险最高的年龄无法抵御缺氧。
