Stevens J P, Daniel T M
Center for International Health, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
Tuber Lung Dis. 1996 Aug;77(4):315-21. doi: 10.1016/s0962-8479(96)90095-7.
North American health care workers with exposure to multidrug-resistant tuberculosis.
To evaluate the relative utilities of bacille Calmette Guérin (BCG) immunization and post-infection chemoprophylaxis for the protection of health care workers exposed to multidrug-resistant Mycobacterium tuberculosis.
Decision analysis using SMLTREE software and published data for probabilities.
BCG vaccination was preferred by a small margin over post-infection chemoprophylaxis. Sensitivity analysis revealed that possible changes in probability values used tended to tilt the result towards use of BCG vaccination. The threshold for protective efficacy of BCG vaccination was 26%.
BCG vaccination should be considered for health care workers in environments where there is a substantial risk of exposure to multidrug-resistant tuberculosis.
接触耐多药结核病的北美医护人员。
评估卡介苗（BCG）免疫接种和感染后化学预防对接触耐多药结核分枝杆菌的医护人员的相对效用。
使用SMLTREE软件进行决策分析，并采用已发表数据作为概率。
卡介苗接种比感染后化学预防略占优势。敏感性分析显示，所使用的概率值的可能变化倾向于使结果偏向于使用卡介苗接种。卡介苗接种的保护效力阈值为26%。
在存在大量接触耐多药结核病风险的环境中，应考虑为医护人员接种卡介苗。
