Brewer T F, Colditz G A
Infectious Disease Unit, Massachusetts General Hospital, Boston.
Clin Infect Dis. 1995 Jan;20(1):136-42. doi: 10.1093/clinids/20.1.136.
For 60 years vaccination with bacille Calmette-Guérin (BCG) has been used for the prevention of tuberculosis in health care workers. In 1988 the U.S. Advisory Committee on Immunization Practices removed the category of health care worker from the list of persons for whom vaccination with BCG should be considered. Nosocomial epidemics of tuberculosis, especially those caused by multidrug-resistant strains, have led to the reconsideration of vaccination with BCG for this population. We review the available studies of the efficacy of BCG vaccine in health care workers. Although the studies had too many methodological flaws to be combined in a quantitative meta-analysis, they suggest that vaccination with BCG is effective in reducing the incidence of tuberculosis among health care workers.
60年来，卡介苗（BCG）一直被用于医护人员预防结核病。1988年，美国免疫实施咨询委员会将医护人员从应考虑接种卡介苗的人群名单中剔除。医院内结核病流行，尤其是由多重耐药菌株引起的流行，促使人们重新考虑对这一人群接种卡介苗。我们回顾了卡介苗疫苗对医护人员有效性的现有研究。尽管这些研究存在太多方法学缺陷，无法进行定量荟萃分析，但它们表明接种卡介苗可有效降低医护人员结核病的发病率。
