Durak I, Bayram F, Kavutcu M, Canbolat O, Oztürk H S
Ankara University Medical Faculty, Biochemistry Department, Türkiye.
J Endocrinol Invest. 1996 May;19(5):312-5. doi: 10.1007/BF03347868.
The activities of total superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) enzymes were measured in cancerous and non-cancerous adjacent tissues from 15 patients with follicular thyroid cancer containing single nodule. SOD and GSH-Px activities were found lower but malondialdehyde levels higher in cancerous tissues compared with those of noncancerous ones. However, no difference was found between CAT activities of the tissues. Activity decrease of GSH-Px enzyme in cancerous tissue was greater than that of SOD enzyme. Results suggested that enzymatic free radical defense system was significantly impaired and lipid peroxidation increased in the cancerous human thyroid tissues.
在15例单发结节性滤泡状甲状腺癌患者的癌组织及癌旁非癌组织中，检测了总超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）的活性。结果发现，癌组织中的SOD和GSH-Px活性低于非癌组织，而丙二醛水平高于非癌组织。然而，两组组织的CAT活性没有差异。癌组织中GSH-Px酶活性的下降幅度大于SOD酶。结果表明，人甲状腺癌组织中的酶促自由基防御系统明显受损，脂质过氧化增加。
