Oudghiri Bouchra, Benzagmout Mohammed, Boujraf Saïd, Belahcen Fawzi, Ibrahimi Adil
Department of Hepatogastroenterology, University Hospital of Fez, Morocco.
J Glob Infect Dis. 2012 Apr;4(2):128-31. doi: 10.4103/0974-777X.96779.
Sarcoidosis is a chronic multisystemic granulomatous disease that is triggered by an autoimmune process. Nowadays, this pathology represents a well-recognized but uncommon complication for antiviral treatment in hepatitis C virus (HCV) infection. Herein, we report a remarkable case of 47-year-old woman treated for chronic HCV infection; the patient has developed interferon alfa-induced sarcoidosis involving the central nervous system. The evolution was fatal despite disrupting the antiviral therapy and initiating a high-dose corticotherapy. This complication of interferon alfa treatment was reported in the literature in only one case. Through this case and a review of the literature, we aim to underline the importance of screening for sarcoidosis before and during the follow-up of HCV patients undergoing antiviral therapy.
结节病是一种由自身免疫过程引发的慢性多系统肉芽肿性疾病。如今，这种病症是丙型肝炎病毒（HCV）感染抗病毒治疗中一种已被充分认识但并不常见的并发症。在此，我们报告一例47岁女性慢性HCV感染治疗的显著病例；该患者发生了干扰素α诱导的累及中枢神经系统的结节病。尽管中断了抗病毒治疗并开始了高剂量皮质激素治疗，病情进展仍导致了死亡。文献中仅报道过一例干扰素α治疗的这种并发症。通过该病例及文献回顾，我们旨在强调在接受抗病毒治疗的HCV患者随访前及随访期间筛查结节病的重要性。
