Kurup V P, Hari V, Guo J, Murali P S, Resnick A, Krishnan M, Fink J N
Department of Medicine, Medical College of Wisconsin, Milwaukee, USA.
Peptides. 1996;17(2):183-90. doi: 10.1016/0196-9781(95)02104-3.
Relevant allergens from Aspergillus fumigatus associated with allergic bronchopulmonary aspergillosis (ABPA) have been cloned and expressed. The pathogenesis of ABPA probably depends on specific cytokines and immunoglobulins secreted by lymphocytes on stimulation with different epitopes of those allergens. In the present study, we synthesized peptides of 12-16 amino acids from the sequence of Asp fI and compared their immunological responses in four mice strains (BALB/c, C57BL/6, AKR, and CBA). Of the five peptides studied for their cytokine profile, one showed a clear Th1, whereas another showed a Th2 response. The remaining three peptides varied in their immunoreactivity. The results suggest that a number of epitopes of diverse activities are present in individual molecules and may be involved in the pathogenesis of ABPA through differential cytokine secretions.
与变应性支气管肺曲霉病（ABPA）相关的烟曲霉的相关变应原已被克隆和表达。ABPA的发病机制可能取决于淋巴细胞在受到这些变应原的不同表位刺激后分泌的特定细胞因子和免疫球蛋白。在本研究中，我们从Asp fI序列合成了12 - 16个氨基酸的肽，并比较了它们在四种小鼠品系（BALB/c、C57BL/6、AKR和CBA）中的免疫反应。在所研究的五种肽的细胞因子谱中，一种显示出明显的Th1反应，而另一种显示出Th2反应。其余三种肽的免疫反应性各不相同。结果表明，单个分子中存在许多具有不同活性的表位，可能通过不同的细胞因子分泌参与ABPA的发病机制。
