磺胺甲氧嗪对大鼠肝脏及血浆中维生素A水平的影响。
The effect of sulphamethoxypyridazine on liver and plasma levels of vitamin A in rats.
作者信息
Bravo M E, Monckeberg F, Urbina J
出版信息
Br J Pharmacol. 1977 Jun;60(2):181-3. doi: 10.1111/j.1476-5381.1977.tb07739.x.
Abstract
1 Long-acting sulphonamides are highly bound to plasma proteins; the present study deals with the effects of this binding property upon a vitamin A compound also transported by plasma proteins. 2 Sulphamethoxypyridazine was administered in rats either orally or by intraperitoneal injection. 3 A significant fall in plasma vitamin A level and an increase in hepatic vitamin A concentration were observed. 4 These results suggest an interference by sulphamethoxypyridazine with the transport of vitamin A, either through competition between the drug and vitamin A for binding sites of plasma proteins, or through altered secretion of the vitamin from the liver.
摘要
- 长效磺胺类药物与血浆蛋白高度结合；本研究探讨了这种结合特性对同样由血浆蛋白转运的一种维生素A化合物的影响。2. 给大鼠口服或腹腔注射磺胺甲氧嗪。3. 观察到血浆维生素A水平显著下降，肝脏维生素A浓度升高。4. 这些结果表明，磺胺甲氧嗪可能通过药物与维生素A竞争血浆蛋白结合位点，或通过改变肝脏中维生素的分泌，干扰维生素A的转运。
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J Clin Invest. 1972 May;51(5):1125-34. doi: 10.1172/JCI106905.
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