Muñoz-Botella S, Martin M A, del Castillo B, Vázquez L
Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain.
Biophys J. 1996 Jul;71(1):86-90. doi: 10.1016/S0006-3495(96)79238-X.
Tapping-mode atomic force microscopy imaging under different cantilever vibration amplitudes has been used to differentiate the host beta-cyclodextrin nanotubes from retinal/beta-cyclodextrin inclusion complex nanotubes. It was observed that both compounds were deformed differently by the applied probe force because of their different local rigidity. This change in the elasticity properties can be explained as a consequence of the inclusion process. This method shows that tapping-mode atomic force microscopy is an useful tool to map soft sample elasticity properties and to distinguish inclusion complexes from their host molecules on the basis of their different mechanical response.
在不同悬臂振动幅度下进行的轻敲模式原子力显微镜成像已被用于区分主体β-环糊精纳米管与视网膜/β-环糊精包合物纳米管。据观察，由于它们不同的局部刚性，这两种化合物在施加的探针力作用下变形方式不同。弹性性质的这种变化可以解释为包合过程的结果。该方法表明，轻敲模式原子力显微镜是一种有用的工具，可用于绘制软样品的弹性性质，并根据其不同的机械响应将包合物与其主体分子区分开来。
