Shikuwa S, Ito M, Nakashima M, Hamasaki K, Naito S, Sekine I, Fujii H
Department of Pathology, Nagasaki University School of Medicine, Japan.
J Gastroenterol. 1996 Feb;31(1):129-32. doi: 10.1007/BF01211200.
We present a rare case of colocalized tumors of hepatocellular carcinoma (HCC) and malignant lymphoma in the liver and bone marrow. A 64-year-old man with hepatitis B virus (HBV)-induced cirrhosis was admitted after detection of elevated serum alpha-fetoprotein level. He was diagnosed as having HCC and treated with chemotherapy and radiotherapy, but the size of the tumors did not diminish. After 11 months' hospitalization, he died due to rupture of esophageal varices. Autopsy revealed two heterogenic malignant tumors, HCC and malignant lymphoma (B cell type), in the liver. These tumors showed colocalization in the liver and bone marrow. The carcinogenetic process of colocalized tumors of HCC and lymphoma was not clarified, but the possibility that persistent HBV infection play a role in promoting hepatocarcinogenic and hematopoietic tumor growths in the reticuloendothelial organs could not be excluded.
我们报告了一例罕见的肝脏和骨髓中同时存在肝细胞癌（HCC）和恶性淋巴瘤的病例。一名64岁的男性，因乙型肝炎病毒（HBV）引起的肝硬化，在血清甲胎蛋白水平升高后入院。他被诊断为患有HCC，并接受了化疗和放疗，但肿瘤大小并未缩小。住院11个月后，他因食管静脉曲张破裂死亡。尸检发现肝脏中有两种异质性恶性肿瘤，即HCC和恶性淋巴瘤（B细胞型）。这些肿瘤在肝脏和骨髓中呈现共定位。HCC和淋巴瘤共定位肿瘤的致癌过程尚不清楚，但不能排除持续的HBV感染在促进网状内皮器官中肝癌和造血肿瘤生长方面发挥作用的可能性。
