Kempf W, Adams V
Department of Dermatology, University Hospital, Zurich, Switzerland.
Biochem Mol Med. 1996 Jun;58(1):1-12. doi: 10.1006/bmme.1996.0025.
Kaposi's sarcoma (KS) is the most frequent malignancy in AIDS patients. Epidemiological studies indicate that a sexually transmitted infections agent other than HIV is involved in the evolution of KS. This "KS agent" may induce a cascade of cytokines which promote the development of the tumor in an autocrine and paracrine mechanism. In this review article several viruses, especially the recently discovered Kaposi's sarcoma herpesvirus (KSHV or HHV-8), are discussed as possible KS agents, and different scenarios of the viral contribution to the pathogenesis of AIDS-associated KS are presented.
卡波西肉瘤（KS）是艾滋病患者中最常见的恶性肿瘤。流行病学研究表明，除HIV外，一种性传播感染因子参与了KS的发展。这种“KS因子”可能会诱导一系列细胞因子，通过自分泌和旁分泌机制促进肿瘤的发展。在这篇综述文章中，讨论了几种病毒，特别是最近发现的卡波西肉瘤疱疹病毒（KSHV或HHV-8）作为可能的KS因子，并介绍了病毒对艾滋病相关KS发病机制的不同作用情况。
