一种基于用牛呼吸道合胞病毒对犊牛进行实验性气溶胶暴露的呼吸道合胞病毒（RSV）感染模型。
A model for respiratory syncytial virus (RSV) infection based on experimental aerosol exposure with bovine RSV in calves.
作者信息
Otto P, Elschner M, Reinhold P, Köhler H, Streckert H J, Philippou S, Werchau H, Morgenroth K
机构信息
Federal Institute for Health Protection of Consumers and Veterinary Medicine, Jena, Germany.
出版信息
Comp Immunol Microbiol Infect Dis. 1996 Feb;19(2):85-97. doi: 10.1016/0147-9571(95)00030-5.
Abstract
Five conventionally kept calves aged between 17 and 24 days were experimentally infected with bovine respiratory syncytial virus (BRSV) by aerosol in order to mimic the natural infection route. The calves were killed and autopsies performed 7 days after the first virus challenge. The BRSV isolate used induced tracheitis, bronchitis and atelectasis in infected calves. The only virus which could be isolated from the lungs of the calves was BRSV. In addition, Mycoplasma bovirhinis was isolated from the lungs or/and trachea of two calves. The clinical and histopathological findings, as well as the detection of BRSV antigens by immunofluorescence in the epithelial cells of lung and trachea, and the reisolation of the virus from bronchoalveolar lavage fluids of all inoculated calves, provided confirmation of successful infection with BRSV.
摘要
为模拟自然感染途径，对5头17至24日龄常规饲养的犊牛进行气溶胶感染牛呼吸道合胞病毒（BRSV）实验。首次病毒攻击7天后，处死犊牛并进行解剖。所使用的BRSV分离株在感染的犊牛中引发了气管炎、支气管炎和肺不张。犊牛肺部唯一可分离出的病毒是BRSV。此外，从两头犊牛的肺或/和气管中分离出了牛鼻支原体。临床和组织病理学发现，以及通过免疫荧光在肺和气管上皮细胞中检测到BRSV抗原，以及从所有接种犊牛的支气管肺泡灌洗液中再次分离出病毒，均证实成功感染了BRSV。
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本文引用的文献
1
The humoral immune response of children and infants to an RSV infection: its maturation and association with illness.儿童和婴儿对呼吸道合胞病毒（RSV）感染的体液免疫反应：其成熟过程及与疾病的关联。
Klin Padiatr. 1995 Nov-Dec;207(6):313-6. doi: 10.1055/s-2008-1046559.
2
Aetiology of community-acquired pneumonia in children treated in hospital.住院治疗的儿童社区获得性肺炎的病因
Eur J Pediatr. 1993 Jan;152(1):24-30. doi: 10.1007/BF02072512.
3
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Respiration. 1995;62(1):27-33. doi: 10.1159/000196385.
4
Modes of transmission of respiratory syncytial virus.呼吸道合胞病毒的传播方式。
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5
[Recommendations for isolation and differentiation of Pasteurella multocida].[多杀巴斯德菌的分离与鉴定建议]
Arch Exp Veterinarmed. 1980;34(5):753-8.
6
Respiratory syncytial virus pneumonia in young calves: clinical and pathologic findings.犊牛呼吸道合胞体病毒肺炎：临床与病理表现
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10
A survey of virus infections of the respiratory tract of cattle and their association with disease.牛呼吸道病毒感染及其与疾病关系的调查
J Hyg (Lond). 1980 Oct;85(2):257-70. doi: 10.1017/s0022172400063294.
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