肾脏去甲肾上腺素溢出与人体肌肉交感神经活动相关。

Renal noradrenaline spillover correlates with muscle sympathetic activity in humans.

Wallin B G, Thompson J M, Jennings G L, Esler M D

Baker Medical Research Institute, Prahan, Victoria, Australia.

J Physiol. 1996 Mar 15;491 ( Pt 3)(Pt 3):881-7. doi: 10.1113/jphysiol.1996.sp021265.

To study the relationship between indices of resting sympathetic traffic in nerves to skeletal muscles and the kidneys, simultaneous measurements were made of muscle sympathetic activity in the peroneal nerve and renal noradrenaline spillover in ten healthy normotensive males aged 18-69 years (mean 42 years). 2. Group mean levels (+/-S.D.) of muscle sympathetic activity and renal spillover were 22 +/- 17 bursts min-1 and 105 +/- 49 ng min-1, respectively. There were significant positive correlations between individual values of muscle sympathetic activity and renal noradrenaline spillover (r = 0.76, P < 0.01) and similarly between muscle sympathetic activity and renal venous plasma concentration of noradrenaline(r = 0.79, P < 0.007). 3. The results indicate that, although the sympathetic system has the capacity for selective activation of different subdivisions, in healthy human subjects resting traffic is similar or proportional in sympathetic nerves to skeletal muscles and the kidney.

为研究支配骨骼肌和肾脏的神经中静息交感神经活动指标之间的关系，对10名年龄在18 - 69岁（平均42岁）的健康血压正常男性，同时测量了腓总神经的肌肉交感神经活动和肾脏去甲肾上腺素溢出量。2. 肌肉交感神经活动和肾脏溢出量的组均值（±标准差）分别为22±17次/分钟和105±49纳克/分钟。肌肉交感神经活动的个体值与肾脏去甲肾上腺素溢出量之间存在显著正相关（r = 0.76，P < 0.01），肌肉交感神经活动与肾脏静脉血浆去甲肾上腺素浓度之间同样存在显著正相关（r = 0.79，P < 0.007）。3. 结果表明，虽然交感神经系统有选择性激活不同分支的能力，但在健康人体中，支配骨骼肌和肾脏的交感神经的静息活动是相似的或成比例的。

Renal noradrenaline spillover correlates with muscle sympathetic activity in humans.