Garcia Rudaz C, Martínez A S, Heinrich J J, Lejarraga H, Keselman A, Laspiur M, Bergadá C
Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.
Ann Hum Biol. 1995 Nov-Dec;22(6):533-44. doi: 10.1080/03014469500004192.
Growth data on 254 patients with Turner syndrome from Argentina-120 with XO karyotype and 134 with other chromosomal abnormalities-were analysed. Birth weight and height were significantly reduced. Ninety patients had received oestrogen treatment from a mean age of 14-0 years (SD 1.2) and 17 patients had spontaneous menarche. Patients who underwent spontaneous menarche had a small growth spurt. Final height was slightly higher (139.8 cm SD 5.6), though not significantly different from the mean adult height of the whole sample (137.9 cm SD 5.7). Mean adult height was 3.73 SD below mean of the normal local population. Mean height velocities from birth to maturity are very similar to those found in other samples. Distance standards were prepared by fitting a fifth-degree polynomial to the interpolated mean heights at each 0.5 year of age, and to the raw SD. Selected centiles were then calculated from the smoothed values. Differences between adult height in local Turner syndrome girls and local normal population are very similar to the same Turner-normal differences described in other communities. Standards presented here are useful for evaluating Turner syndrome patients from Argentina, and may also be used by those with similar growth pattern in their normal population.
分析了来自阿根廷的254例特纳综合征患者的生长数据，其中120例核型为XO，134例有其他染色体异常。出生体重和身高显著降低。90例患者从平均14.0岁（标准差1.2）开始接受雌激素治疗，17例有自然月经初潮。经历自然月经初潮的患者有一次小的生长突增。最终身高略高（139.8厘米，标准差5.6），但与整个样本的平均成人身高（137.9厘米，标准差5.7）无显著差异。平均成人身高比当地正常人群的平均值低3.73个标准差。从出生到成熟的平均身高增长速度与其他样本中的非常相似。通过将五次多项式拟合到每0.5岁的插值平均身高以及原始标准差来制定距离标准。然后从平滑值计算选定的百分位数。当地特纳综合征女孩的成人身高与当地正常人群之间的差异与其他群体中描述的特纳综合征患者与正常人之间的差异非常相似。这里给出的标准有助于评估来自阿根廷的特纳综合征患者，生长模式与其正常人群相似的地区也可使用。
