Cipolla C, Magliocco A, Oliva L, Cottone M
Clinica Medica R Ospedale V. Cervello, Palermo, Italy.
Eur J Epidemiol. 1996 Apr;12(2):205-10. doi: 10.1007/BF00145508.
To evaluate familial aggregation of inflammatory bowel disease (IBD) in the Mediterranean area and to estimate the disease risk in first degree relatives. 427 patients with IBD were consecutively interviewed in order to obtain a complete pedigree of first degree relatives. Sufficient information was obtained in 98% of 2,685 family members. The prevalence ratio of IBD in family members was estimated and compared to the prevalence ratio of IBD in general population; the ratio was then standardized by age since the prevalence of the disease is age-dependent. The lifetime risk was assessed by the Kaplan Meier method. Thirty index cases (7%) had at least one affected first degree relative. As compared with the general population, first degree relatives of the 427 patients with IBD had a 4.38-fold increase in the age corrected risk of having the same disease. The kaplan-Meier curve showed a higher risk at 25 years of age for offsprings (3%) than for parents (1%) and siblings (1%) whereas the crude ratio showed a higher risk for siblings (1.9%) compared to parents (0.8%) and offsprings (1%). In the Mediterranean area, the familial prevalence of IBD is higher than in the general population and comparable to North European rates.
为评估地中海地区炎症性肠病（IBD）的家族聚集性，并估计一级亲属的患病风险。对427例IBD患者进行了连续访谈，以获取完整的一级亲属谱系。在2685名家庭成员中，98%的人获得了足够的信息。估计了家庭成员中IBD的患病率，并与普通人群中IBD的患病率进行比较；由于疾病患病率与年龄有关，因此该比率按年龄进行了标准化。通过Kaplan Meier方法评估终生风险。30例索引病例（7%）至少有一名患病的一级亲属。与普通人群相比，427例IBD患者的一级亲属患同一种疾病的年龄校正风险增加了4.38倍。Kaplan-Meier曲线显示，25岁时后代（3%）的风险高于父母（1%）和兄弟姐妹（1%），而粗比率显示，兄弟姐妹（1.9%）的风险高于父母（0.8%）和后代（1%）。在地中海地区，IBD的家族患病率高于普通人群，与北欧患病率相当。
