Rautelin H, Sipponen P, Seppälä K, Sarna S, Danielsson D, Kosunen T U
Dept. of Bacteriology and Immunology, University of Helsinki, Finland.
Scand J Gastroenterol. 1996 Jul;31(7):639-42. doi: 10.3109/00365529609009142.
Some Helicobacter pylori strains activate human neutrophils without opsonins and/or produce vacuolating cytotoxin.
Human gastric isolates of H. pylori were studied for their ability to nonopsonized induce an oxidative burst in human neutrophils as measured by chemiluminescence and for the production of vacuolating cytotoxin. In all, 80 strains were examined, and the type and grade of inflammation in the gastric biopsy specimens from the antrum and corpus of these patients were assessed in accordance with the Sydney system.
CL+ (rapid, strong response in chemiluminescence) strains (p < 0.0001) and Tox+ (cytotoxin-producing) strains (p < 0.0001) were associated with higher acute inflammation scores in gastric ulcer patients. CL+ (p = 0.0002) and Tox+ (p < 0.0001) strains were also associated with higher chronic inflammation scores in gastric ulcer patients.
CL+ and Tox+ strains seem to cause more severe inflammation in the gastric mucosa during H. pylori infection.
一些幽门螺杆菌菌株可在无调理素的情况下激活人类中性粒细胞和/或产生空泡毒素。
研究幽门螺杆菌的人胃分离株通过化学发光法检测其在无调理素时诱导人类中性粒细胞产生氧化爆发的能力以及空泡毒素的产生情况。共检测了80株菌株，并根据悉尼系统评估这些患者胃窦和胃体活检标本中的炎症类型和程度。
CL+（化学发光快速、强烈反应）菌株（p<0.0001）和Tox+（产毒素）菌株（p<0.0001）与胃溃疡患者更高的急性炎症评分相关。CL+（p = 0.0002）和Tox+（p<0.0001）菌株也与胃溃疡患者更高的慢性炎症评分相关。
CL+和Tox+菌株似乎在幽门螺杆菌感染期间导致胃黏膜更严重的炎症。
