McPherson S, La Rue A, Fitz A, Matsuyama S, Jarvik L F
Neuroscience Associates, Los Angeles, California, USA.
Int Psychogeriatr. 1995 Fall;7(3):367-76. doi: 10.1017/s1041610295002110.
This study examined the relationship between subjective memory complaints and performance on tests of memory by relatives of patients with probable Alzheimer's disease (AD) and by older adults without a family history of dementia. Relatives of AD patients did not differ significantly from controls either in level of complaint or in performance on neuropsychological tests. However, among relatives of patients with early-onset AD, significant correlations were found between performance on memory tests and self-rated changes in everyday memory. These findings raise the possibility that relatives who have entered the age range in which their parents or siblings developed dementia symptoms are monitoring their memory performance more diligently than relatives of patients whose illness began at much later ages or persons who have no close relatives with AD.
本研究调查了可能患有阿尔茨海默病（AD）患者的亲属以及无痴呆家族史的老年人的主观记忆抱怨与记忆测试表现之间的关系。AD患者的亲属在抱怨程度或神经心理学测试表现上与对照组相比均无显著差异。然而，在早发性AD患者的亲属中，发现记忆测试表现与日常记忆的自评变化之间存在显著相关性。这些发现增加了一种可能性，即已进入其父母或兄弟姐妹出现痴呆症状年龄范围的亲属，比那些亲属患病年龄晚得多的患者的亲属或没有患AD近亲的人，会更密切地监测自己的记忆表现。
