新的对醌型阿朴啡生物碱以及墨西哥莲叶桐的抗血小板聚集成分

New p-quinonoid aporphine alkaloids and antiplatelet aggregation constituents of Hernandia sonora.

作者信息

Chen I S, Chen J J, Tsai I L, Chang Y L, Teng C M

机构信息

Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.

出版信息

Planta Med. 1995 Dec;61(6):537-9. doi: 10.1055/s-2006-959366.

DOI:10.1055/s-2006-959366

PMID:8824949

Abstract

Three minor new p-quinonoid aporphine alkaloids, sonodione (1), demethylsonodione (2), and norsonodione (3), have been additionally isolated from the stem bark of Hernandia sonora. The structures of these compounds were elucidated by spectral analysis. Among the isolates obtained till now, five compounds, ovigerine (4), hernangerine (5), N-methylhernangerine (6), (+)-malekulatine (7), and isovanillin (8) showed moderate antiplatelet aggregation activity in vitro.

摘要

另外，从索诺拉莲叶桐的茎皮中分离出了三种新的次要对醌型阿朴啡生物碱，即索诺二酮（1）、去甲基索诺二酮（2）和降索诺二酮（3）。通过光谱分析阐明了这些化合物的结构。在迄今获得的分离物中，五种化合物，即卵叶番荔枝碱（4）、莲叶桐碱（5）、N-甲基莲叶桐碱（6）、（+）-马来库拉汀（7）和异香草醛（8）在体外表现出中等程度的抗血小板聚集活性。