人类6号染色体上GLO - Bf - HLA - A - PGM3连锁群的图谱顺序。

Map order of the linkage group GLO-Bf-HLA-A-PGM3 on human chromosome 6.

作者信息

Kömpf J, Bissbort S, Göhler F, Schunter F, Wernet P

出版信息

Scand J Immunol. 1977;6(5):453-7. doi: 10.1111/j.1365-3083.1977.tb02102.x.

DOI:10.1111/j.1365-3083.1977.tb02102.x

Abstract

Linkage analysis of 52 families with 181 children confirms close linkage for GLO-Bf, GLO-HLA-A, and Bf-HLA-A and proves linkage between HLA-A and PGM3. Linkage for Bf-PGM3 and GLO-PGM3, respectively, seems to be likely; close linkage can be excluded. From the relative map distances, but above all from the segregation of defined linkage phases in crossover families, we can hypothesize that the sequence order of the loci should be GLO-Bf-HLA-A-PGM3.

摘要

对52个家庭共181名儿童进行的连锁分析证实，GLO - Bf、GLO - HLA - A和Bf - HLA - A之间存在紧密连锁，并证明了HLA - A与PGM3之间的连锁关系。Bf - PGM3和GLO - PGM3之间分别似乎可能存在连锁关系；可以排除紧密连锁。从相对图谱距离来看，更重要的是从交叉家庭中确定的连锁阶段的分离情况，我们可以推测这些基因座的序列顺序应该是GLO - Bf - HLA - A - PGM3。