Nikolaizik W H, Jenni-Galović V, Schöni M H
Alpine Children's Hospital, Davos Platz, Switzerland.
Eur J Pediatr. 1996 Jul;155(7):608-11. doi: 10.1007/BF01957914.
To assess the airway response to inhaled tobramycin we measured flow volume curves in 12 patients with cystic fibrosis. Immediately and/or 2 min after tobramycin inhalations there was a significant fall in lung function regardless of the concentration used; isotonic saline caused similar obstruction but not a complete cessation of peripheral airflows. The baseline oxygen saturation was significantly correlated with the fall in lung function. Ten minutes after inhalation lung function tests returned to baseline values.
As salbutamol could significantly reduce airway obstruction tobramycin should always be inhaled in combination with a bronchodilator.
为评估吸入妥布霉素后的气道反应，我们对12例囊性纤维化患者测量了流量-容积曲线。无论使用何种浓度，在吸入妥布霉素后即刻和/或2分钟时，肺功能均显著下降；等渗盐水也会导致类似的阻塞，但不会使外周气流完全停止。基线氧饱和度与肺功能下降显著相关。吸入后10分钟，肺功能测试恢复到基线值。
由于沙丁胺醇可显著减轻气道阻塞，妥布霉素应始终与支气管扩张剂联合吸入。
