Lindström E, Lindström L H
Department of Psychiatry, University Hospital, Uppsala, Sweden.
Eur Arch Psychiatry Clin Neurosci. 1996;246(4):219-23. doi: 10.1007/BF02188957.
The Comprehensive Psychopathological Rating Scale (CPRS) was used to determine symptomatology in 145 schizophrenic patients. In 40 of these patients the Schedule for Assessment of Negative Symptoms (SANS) was also applied in order to determine which items in the CPRS represent negative schizophrenic symptoms. Of the patients, 115 were drug-free and 30 were treated with major tranquilizers at the time of the rating. A principal component analysis with oblique solution and Varimax rotation grouped the items from CPRS into ten factors. These factors were subsequently correlated to the total scores of the SANS. When a factor showed a positive correlation with the SANS, the individual items within the factor were examined for correlation to both the subscales and the total SANS scores. Of the 33 items, 5 used in the CPRS showed a positive correlation with the SANS and were therefore considered to represent negative symptomatology in schizophrenia. These items were withdrawal, reduced speech, lack of appropriate emotions, slowness of movements and indecision. The items were grouped as a negative symptom subscale in the CPRS.
采用综合精神病理学评定量表（CPRS）对145例精神分裂症患者的症状进行评定。其中40例患者还应用了阴性症状评定量表（SANS），以确定CPRS中的哪些项目代表精神分裂症的阴性症状。在评定时，115例患者未服用药物，30例患者正在接受大剂量镇静剂治疗。采用具有斜交解和方差最大化旋转的主成分分析将CPRS中的项目分为10个因子。随后将这些因子与SANS的总分进行相关性分析。当一个因子与SANS呈正相关时，就对该因子内的各个项目与SANS的各分量表分数及总分进行相关性分析。在CPRS所使用的33个项目中，有5个与SANS呈正相关，因此被认为代表精神分裂症的阴性症状。这些项目为退缩、言语减少、缺乏适当情感、动作迟缓及犹豫不决。这些项目在CPRS中被归为一个阴性症状分量表。
