Wakatsuki T, Hirata F, Ohno H, Yamamoto M, Sato Y, Ohira Y
Department of Physiology and Biomechanics, National Institute of Fitness and Sports, Kanoya, Japan.
Jpn J Physiol. 1996 Apr;46(2):171-5. doi: 10.2170/jjphysiol.46.171.
Effects of chronic depletion of high-energy phosphate compounds by feeding beta-guanidinopropionic acid (beta-GPA) with or without hindlimb suspension (HS) on body temperature were studied in rats. Lower rectal and skin temperatures were observed in rats after 10 d of HS. Suspension-related enlargement of the interscapular brown adipose tissue (BAT), associated with adrenal hypertrophy, was seen. Feeding beta-GPA also caused a hypothermia and BAT enlargement. It is suggested that the hypothermic response to HS may be due to decreased contractile activity and metabolic rate in skeletal muscles, associated with stress. It is also speculated that the changes in the thermogenesis in rats fed beta-GPA might be related to a stimulated ATP synthesis with sacrificed heat production, but not associated with stress.
通过给大鼠喂食β-胍基丙酸（β-GPA），无论有无后肢悬吊（HS），研究慢性消耗高能磷酸化合物对体温的影响。HS 10天后观察到大鼠直肠和皮肤温度降低。可见肩胛间棕色脂肪组织（BAT）因悬吊而增大，并伴有肾上腺肥大。喂食β-GPA也会导致体温过低和BAT增大。提示对HS的低温反应可能是由于与应激相关的骨骼肌收缩活动和代谢率降低所致。还推测，喂食β-GPA的大鼠产热变化可能与牺牲产热刺激ATP合成有关，但与应激无关。
