Guan X J, Arhin G, Leung J, Tilghman S M
Department of Molecular Biology, Princeton University, New Jersey 08544, USA.
Mamm Genome. 1996 Feb;7(2):103-6. doi: 10.1007/s003359900028.
The albumin gene family consists of four evolutionarily related genes that code for serum transport proteins. In rodents, the genes for albumin, alpha-fetoprotein, and alpha ALB are physically linked within 100 kilobases of DNA. The fourth gene, Gc, encoding vitamin D-binding protein or group-specific component, maps to the same chromosome as the other family members, but linkage has not been established. This report describes the genetic and physical mapping of Gc in mouse and establishes that, although Gc is genetically linked to the other genes, its physical distance from them extends beyond the resolution range of yeast artificial chromosome cloning and pulsed-field gel electrophoresis.
白蛋白基因家族由四个在进化上相关的基因组成，这些基因编码血清转运蛋白。在啮齿动物中，白蛋白、甲胎蛋白和α-ALB的基因在100千碱基的DNA范围内物理相连。第四个基因Gc，编码维生素D结合蛋白或组特异性成分，与其他家族成员定位于同一条染色体上，但尚未确定其连锁关系。本报告描述了小鼠中Gc基因的遗传和物理图谱，并确定尽管Gc在遗传上与其他基因连锁，但其与它们的物理距离超出了酵母人工染色体克隆和脉冲场凝胶电泳的分辨率范围。
