Simpson C, Garabrant D, Torrey S, Robins T, Franzblau A
Department of Environmental and Industrial Health, University of Michigan, School of Public Health, Ann Arbor 48109-2029, USA.
Am J Ind Med. 1996 Jul;30(1):48-55. doi: 10.1002/(SICI)1097-0274(199607)30:1<48::AID-AJIM8>3.0.CO;2-O.
Twenty-three of 34 workers who had worked in the injection molding operation making polyurethane foam parts at an automobile parts manufacturing plant developed respiratory symptoms and/or systemic symptoms over a 2-month period following the full production use of a new diisocyanate paint that contained 1,3-bis(isocyanatomethyl)cyclohexane pre-polymer (BIC)(CAS #75138-76-0, 38661-72-2). At 3 months, all subjects underwent an interview, physical examination, pre- and post-shift pulmonary function tests, and either methacholine challenge test or bronchodilator challenge at an occupational health clinic. The most frequently cited symptoms were dyspnea (65%), cough (61%), chest tightness (57%), chills (57%), wheezing (30%), and myalgias, arthralgias, and nausea (26%). Thirteen subjects had either a positive methacholine challenge test or a positive response to bronchodilator challenge, making the overall prevalence of airway hyperresponsiveness 38%. The overall prevalence of hypersensitivity pneumonitis-like reactions among line operators in the injection molding process was 27%. This disease outbreak suggests that 1,3-bis(isocyanatomethyl)cyclohexane pre-polymer may cause asthma and hypersensitivity pneumonitis-like reactions. The use of BIC was discontinued 6 months after the first workers developed symptoms.
在一家汽车零部件制造工厂，34名从事聚氨酯泡沫部件注塑作业的工人中，有23人在全面生产使用一种含有1,3 - 双（异氰酸酯甲基）环己烷预聚物（BIC）（化学物质登记号#75138 - 76 - 0，38661 - 72 - 2）的新型二异氰酸酯涂料后的2个月内出现了呼吸道症状和/或全身症状。3个月时，所有受试者在职业健康诊所接受了访谈、体格检查、班前和班后肺功能测试，以及乙酰甲胆碱激发试验或支气管扩张剂激发试验之一。最常提及的症状是呼吸困难（65%）、咳嗽（61%）、胸闷（57%）、寒战（57%）、喘息（30%）以及肌痛、关节痛和恶心（26%）。13名受试者的乙酰甲胆碱激发试验呈阳性或对支气管扩张剂激发试验有阳性反应，使得气道高反应性的总体患病率为38%。注塑过程中生产线操作人员中类似过敏性肺炎反应的总体患病率为27%。这次疾病暴发表明1,3 - 双（异氰酸酯甲基）环己烷预聚物可能会导致哮喘和类似过敏性肺炎的反应。在首批工人出现症状6个月后，停止了BIC的使用。
