大鼠体内留存的叶酸。
Retained folates in the rat.
作者信息
Barford P A, Staff R J, Blair J A
出版信息
Biochem J. 1977 Jun 15;164(3):601-5. doi: 10.1042/bj1640601.
Abstract
The retention of radioactivity after doses of 14C- and 3H-labelled folic acid is described. Radioactivity was retained in liver, kidney and gut of rats for some time after administration of the dose. The retained radioactivity could not be displaced by large doses of unlabelled folic acid or unlabelled 5-methyltetrahydrofolate. 14C- and 3H-labbelled folates showed similar chromatographic behaviour onion-exchange chromatography to 5-methyltetrahydrofolate, and on ion-exchange and gel-permeation chromatography to synthetic pteroylhepta-gamma-glutamate.
摘要
描述了给予14C和3H标记的叶酸剂量后放射性的保留情况。给药后，放射性在大鼠的肝脏、肾脏和肠道中保留了一段时间。大剂量的未标记叶酸或未标记的5-甲基四氢叶酸不能取代保留的放射性。14C和3H标记的叶酸在离子交换色谱上与5-甲基四氢叶酸表现出相似的色谱行为，在离子交换和凝胶渗透色谱上与合成的蝶酰庚聚谷氨酸表现出相似的色谱行为。
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