Massry G G, Hornblass A, Harrison W
Department of Ophthalmology, St. Louis University School of Medicine, Anheuser-Busch Eye Institute, USA.
Ophthalmology. 1996 Sep;103(9):1467-70. doi: 10.1016/s0161-6420(96)30482-x.
Sino-orbital aspergillosis is typically treated with surgical debridement and intravenous amphotericin B. Some authors have advocated intraorbital irrigation or injection of amphotericin B in specific cases.
An immunocompetent patient with recurrent sino-orbital aspergillosis is presented. After failing two attempts at traditional therapeutic modalities, treatment with oral itraconazole was initiated.
The patient has had resolution of her sino-orbital disease without recurrence at 10 months of follow-up.
In immunocompetent patients with orbital aspergillosis, itraconazole should be considered as a treatment option in patients who have recurrent or recalcitrant disease, or in those who cannot tolerate amphotericin B.
鼻窦眶部曲霉菌病通常采用手术清创和静脉注射两性霉素B进行治疗。一些作者主张在特定病例中进行眶内冲洗或注射两性霉素B。
报告一例免疫功能正常但患有复发性鼻窦眶部曲霉菌病的患者。在两次传统治疗方法尝试失败后，开始使用口服伊曲康唑进行治疗。
该患者的鼻窦眶部疾病得到缓解，随访10个月无复发。
对于患有眶部曲霉菌病的免疫功能正常患者，对于复发或难治性疾病患者，或不能耐受两性霉素B的患者，应考虑将伊曲康唑作为一种治疗选择。
