Hain C, Maier W, Hoechst-Janneck S, Franke P
Department of Psychiatry, University of Mainz, Germany.
Acta Psychiatr Scand. 1995 Oct;92(4):305-9. doi: 10.1111/j.1600-0447.1995.tb09587.x.
To assess the frequency and quality of formal thought disorder in schizophrenic patients and their first-degree relatives, a consecutive series of 36 unmedicated patients, 20 siblings of these patients and 37 normal control subjects were examined with Holzman's Thought Disorder Index (TDI). As a proof of the internal validity of this tool, the patients demonstrated significantly more thought disorder than the controls as measured by the TDI total score and various subscores, which proved the internal validity of this tool in a German-speaking sample. In addition, in a pairwise comparison with controls who were individually matched by age and sex the patients' siblings had a significantly higher total TDI score and nonsignificant elevations on several subscores (combinatory and flippant). As to the level of severity of the thought disorder, the siblings mostly took an intermediate position between patients and controls. In conjunction with previous reports from other authors, our findings lend further support to the notion of subclinical thought disorder as an indicator of familial vulnerability to schizophrenia.
为评估精神分裂症患者及其一级亲属中形式思维障碍的频率和质量，我们使用霍尔兹曼思维障碍指数（TDI）对连续的36名未服药患者、这些患者的20名兄弟姐妹以及37名正常对照者进行了检查。作为该工具内部效度的一个证据，通过TDI总分及各个子分数测量，患者表现出比对照者明显更多的思维障碍，这证明了该工具在德语样本中的内部效度。此外，在与按年龄和性别进行个体匹配的对照者的两两比较中，患者的兄弟姐妹TDI总分显著更高，并且在几个子分数（组合和轻率）上有不显著的升高。至于思维障碍的严重程度水平，兄弟姐妹大多处于患者和对照者之间的中间位置。结合其他作者之前的报告，我们的研究结果进一步支持了亚临床思维障碍作为精神分裂症家族易感性指标这一观点。
