Blum A S, Drislane F W
Department of Neurology, Beth Israel Hospital, Boston, MA 02215, USA.
Neurology. 1996 Oct;47(4):1079-81. doi: 10.1212/wnl.47.4.1079.
Fluctuating neurologic symptoms, including confusion, stupor, and convulsions, are common signs in thrombotic thrombocytopenic purpura (TTP). We describe a patient with TTP who had a clinical seizure, intermittent stupor, and a declining course despite aggressive treatment. An EEG showed continuous rhythmic epileptiform discharges, and she improved with anticonvulsants. Fluctuating stupor in TTP has generally been attributed to microvascular occlusive disease, but nonconvulsive status epilepticus is a treatable condition that can cause similar symptoms.
包括意识模糊、昏迷和惊厥在内的波动性神经症状是血栓性血小板减少性紫癜（TTP）的常见体征。我们描述了一名患有TTP的患者，尽管接受了积极治疗，但仍出现临床癫痫发作、间歇性昏迷且病情不断恶化。脑电图显示有持续的节律性癫痫样放电，使用抗惊厥药物后她的病情有所改善。TTP中的波动性昏迷通常归因于微血管闭塞性疾病，但非惊厥性癫痫持续状态是一种可治疗的病症，可导致类似症状。
