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结核性脑膜炎患者脑脊液中3-(2'-酮己基)吲哚啉的电子捕获气相色谱检测及质谱鉴定

Electron capture gas chromatography detection and mass spectrum identification of 3-(2'-ketohexyl)indoline in spinal fluids of patients with tuberculous meningitis.

作者信息

Brooks J B, Choudhary G, Craven R B, Alley C C, Liddle J A, Edman D C, Converse J D

出版信息

J Clin Microbiol. 1977 Jun;5(6):625-8. doi: 10.1128/jcm.5.6.625-628.1977.

DOI:10.1128/jcm.5.6.625-628.1977
PMID:886002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC274668/
Abstract

A basic, extractable, indolic type of compound, which was derivatized with heptafluorobutyric anhydride and pyridine, was obtained from the cerebrospinal fluids of patients with acute tuberculous meningitis. The compound was detected by frequency-pulsed, modulated electron capture gas-liquid chromatography, and it was tentatively identified by mass spectrometry as 3-(2'-ketohexyl)indoline. The compound was found to be valuable for differentiating between tuberculous, cryptococcal, and aseptic meningitides.

摘要

从急性结核性脑膜炎患者的脑脊液中获得了一种基本的、可提取的吲哚类化合物，该化合物用七氟丁酸酐和吡啶进行了衍生化。通过频率脉冲调制电子捕获气液色谱法检测该化合物，并通过质谱法初步鉴定为3-(2'-酮己基)吲哚啉。发现该化合物对于鉴别结核性、隐球菌性和无菌性脑膜炎有价值。

相似文献

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Electron capture gas chromatography detection and mass spectrum identification of 3-(2'-ketohexyl)indoline in spinal fluids of patients with tuberculous meningitis.结核性脑膜炎患者脑脊液中3-(2'-酮己基)吲哚啉的电子捕获气相色谱检测及质谱鉴定
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引用本文的文献

1
Frequency-pulsed electron capture gas-liquid chromatography and the tryptophan color test for rapid diagnosis of tuberculous and other forms of lymphocytic meningitis.频率脉冲电子捕获气液色谱法及色氨酸颜色试验用于快速诊断结核性及其他形式的淋巴细胞性脑膜炎。
J Clin Microbiol. 1980 Aug;12(2):208-15. doi: 10.1128/jcm.12.2.208-215.1980.
2
Rapid diagnosis of lymphocytic meningitis by frequency-pulsed electron capture gas-liquid chromatography: differentiation of tuberculous, cryptococcal, and viral meningitis.频率脉冲电子捕获气液色谱法对淋巴细胞性脑膜炎的快速诊断：结核性、隐球菌性和病毒性脑膜炎的鉴别
J Clin Microbiol. 1977 Jul;6(1):27-32. doi: 10.1128/jcm.6.1.27-32.1977.
3
Electron capture gas-liquid chromatographic study of metabolites produced by some arthritic transudate-associated organisms in vitro and in vivo in rabbit models.电子捕获气液色谱法对兔模型体内外某些与关节炎渗出液相关生物产生的代谢产物的研究。
J Clin Microbiol. 1978 Oct;8(4):402-9. doi: 10.1128/jcm.8.4.402-409.1978.
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Demonstration of tuberculostearic acid in sputum from patients with pulmonary tuberculosis by selected ion monitoring.通过选择离子监测法检测肺结核患者痰液中的结核硬脂酸
J Clin Invest. 1979 May;63(5):813-9. doi: 10.1172/JCI109380.

本文引用的文献

1
Analysis of pineal and brain indole alkylamines by gas chromatography-mass spectrometry.气相色谱-质谱联用分析松果体和脑内吲哚烷基胺
Adv Biochem Psychopharmacol. 1973;7:33-43.