结核性脑膜炎患者脑脊液中3-(2'-酮己基)吲哚啉的电子捕获气相色谱检测及质谱鉴定
Electron capture gas chromatography detection and mass spectrum identification of 3-(2'-ketohexyl)indoline in spinal fluids of patients with tuberculous meningitis.
作者信息
Brooks J B, Choudhary G, Craven R B, Alley C C, Liddle J A, Edman D C, Converse J D
出版信息
J Clin Microbiol. 1977 Jun;5(6):625-8. doi: 10.1128/jcm.5.6.625-628.1977.
Abstract
A basic, extractable, indolic type of compound, which was derivatized with heptafluorobutyric anhydride and pyridine, was obtained from the cerebrospinal fluids of patients with acute tuberculous meningitis. The compound was detected by frequency-pulsed, modulated electron capture gas-liquid chromatography, and it was tentatively identified by mass spectrometry as 3-(2'-ketohexyl)indoline. The compound was found to be valuable for differentiating between tuberculous, cryptococcal, and aseptic meningitides.
摘要
从急性结核性脑膜炎患者的脑脊液中获得了一种基本的、可提取的吲哚类化合物，该化合物用七氟丁酸酐和吡啶进行了衍生化。通过频率脉冲调制电子捕获气液色谱法检测该化合物，并通过质谱法初步鉴定为3-(2'-酮己基)吲哚啉。发现该化合物对于鉴别结核性、隐球菌性和无菌性脑膜炎有价值。
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