Spiers D R, Wade R C
Dominion Pharma Ltd, Haslemere, Surrey, UK.
Curr Med Res Opin. 1996;13(7):409-15. doi: 10.1185/03007999609111560.
In a double-blind, partial cross-over study of 141 patients with mild to moderate hypertension, chlorthalidone 50 mg was compared with chlorthalidone 50 mg/triamterene 50 mg combination treatment. The study assessed clinical efficacy in the reduction of blood pressure, and safety with regard to serum potassium concentration and adverse reactions. Both treatment regimens were found to offer equivalent therapeutic success, but the decrease in serum potassium concentration was significantly less with the combination treatment than with chlorthalidone alone.
在一项针对141例轻至中度高血压患者的双盲、部分交叉研究中，对50毫克氯噻酮与50毫克氯噻酮/50毫克氨苯蝶啶联合治疗进行了比较。该研究评估了降低血压的临床疗效以及血清钾浓度和不良反应方面的安全性。发现两种治疗方案的治疗成功率相当，但联合治疗组血清钾浓度的降低明显低于单独使用氯噻酮组。
