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乙型和丙型肝炎病毒与原发性肝癌

Hepatitis B and C viruses and primary liver cancer.

作者信息

Brechot C

机构信息

INSERM U370 and Liver Unit, CHU Necker, Paris, France.

出版信息

Baillieres Clin Gastroenterol. 1996 Jul;10(2):335-73. doi: 10.1016/s0950-3528(96)90010-x.

DOI:10.1016/s0950-3528(96)90010-x
PMID:8864037
Abstract

The data presented indicate that viral agents (namely, HBV and HCV) are major environmental aetiological factors for human primary liver cancer. It is important to elucidate the molecular mechanisms further because HCC is one of the few examples of virus-related human cancers. In addition, the available evidence points to the possibility of at least partial prevention of the tumour by large-scale vaccination.

摘要

所呈现的数据表明,病毒因子(即乙肝病毒和丙肝病毒)是人类原发性肝癌的主要环境病因因素。进一步阐明分子机制很重要,因为肝癌是少数与病毒相关的人类癌症之一。此外,现有证据表明通过大规模疫苗接种至少有可能部分预防肿瘤。

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引用本文的文献

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Cochrane Database Syst Rev. 2007 Oct 17;2007(4):CD003181. doi: 10.1002/14651858.CD003181.pub2.
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Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection.β-连环蛋白突变在与丙型肝炎病毒感染相关的人类肝细胞癌中很常见。
Am J Pathol. 1999 Dec;155(6):1795-801. doi: 10.1016/s0002-9440(10)65496-x.
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[Hepatitis B virus and pathogenesis].[乙型肝炎病毒与发病机制]
Soz Praventivmed. 1998;43 Suppl 1:S5-9, S79-83. doi: 10.1007/BF02042164.