Heron C, Gould T J, Bickford P
Veterans Administration Medical Center, Denver, CO, USA.
Behav Brain Res. 1996 Aug;78(2):235-41. doi: 10.1016/0166-4328(95)00252-9.
Performance of rats on a motor learning paradigm that has been demonstrated to be dependent upon cerebellar norepinephrine (NE) was studied in male F344 rats treated with an alpha 1 antagonist (prazosin), an alpha 2 antagonist (yohimbine) or a beta noradrenergic antagonist (propranolol). The ability of propranolol-treated rats (10 mg/kg i.p. 30 min prior to daily testing) to acquire proficiency on the novel motor task was impaired while prazosin-treated rats' (0.5 mg/kg i.p. 30 min prior to daily testing) and yohimbine-treated rats' (1 mg/kg i.p. 30 min prior to daily testing) rates of acquisition of the novel motor task were not different from controls. In an attempt to distinguish between alterations in motor coordination and motor learning, additional tests of psychomotor performance were assessed for all groups of rats. These examinations included a walking test on 2.5 and 5 cm rods and speed of running on the motor task. The data indicate that drug-treated rats show no difference from controls on the above parameters. Some differences, however, were observed between propranolol and controls in the time spent in the goal box. Overall, the data are consistent with our hypothesis that the beta noradrenergic receptor is involved in the ability to acquire novel motor tasks.
在雄性F344大鼠中，研究了用α1拮抗剂（哌唑嗪）、α2拮抗剂（育亨宾）或β肾上腺素能拮抗剂（普萘洛尔）处理后，大鼠在一种已被证明依赖于小脑去甲肾上腺素（NE）的运动学习范式中的表现。普萘洛尔处理的大鼠（每日测试前30分钟腹腔注射10毫克/千克）在新运动任务上获得熟练程度的能力受损，而哌唑嗪处理的大鼠（每日测试前30分钟腹腔注射0.5毫克/千克）和育亨宾处理的大鼠（每日测试前30分钟腹腔注射1毫克/千克）在新运动任务上的习得率与对照组没有差异。为了区分运动协调和运动学习的改变，对所有大鼠组进行了额外的精神运动表现测试。这些检查包括在2.5厘米和5厘米杆上的行走测试以及在运动任务上的奔跑速度。数据表明，药物处理的大鼠在上述参数上与对照组没有差异。然而，在目标箱中停留的时间方面，普萘洛尔组与对照组之间观察到了一些差异。总体而言，数据与我们的假设一致，即β肾上腺素能受体参与了获得新运动任务的能力。
