“携带者”和“非携带者”牛的血清及分泌物中针对口蹄疫病毒的同型特异性抗体反应
Isotype-specific antibody responses to foot-and-mouth disease virus in sera and secretions of "carrier' and "non-carrier' cattle.
作者信息
Salt J S, Mulcahy G, Kitching R P
机构信息
Institute for Animal Health, Pirbright Laboratory, Surrey, UK.
出版信息
Epidemiol Infect. 1996 Oct;117(2):349-60. doi: 10.1017/s0950268800001539.
Abstract
Isotype-specific antibody responses to foot-and-mouth disease virus (FMDV) were measured in the sera and upper respiratory tract secretions of vaccinated and susceptible cattle challenged with FMDV by direct contact or by intranasal inoculation. A comparison was made between cattle that eliminated FMDV and those that developed and maintained a persistent infection. Serological and mucosal antibody responses were detected in all animals after challenge. IgA and IgM were detected before the development of IgG1 and IgG2 responses. IgM was not detected in vaccinated cattle. Challenge with FMDV elicited a prolonged biphasic secretory antibody response in FMDV "carrier' animals only. The response was detected as FMDV-specific IgA in both mucosal secretions and serum samples, which gained statistical significance (P < 0.05) by 5 weeks after challenge. This observation could represent the basis of a test to differentiate vaccinated and/or recovered convalescent cattle from FMDV "carriers'.
摘要
通过直接接触或鼻内接种口蹄疫病毒（FMDV），对接种疫苗和易感牛进行攻击，检测其血清和上呼吸道分泌物中对口蹄疫病毒的同型特异性抗体反应。对清除FMDV的牛和发生并维持持续性感染的牛进行了比较。攻击后在所有动物中均检测到血清学和黏膜抗体反应。在IgG1和IgG2反应出现之前就检测到了IgA和IgM。在接种疫苗的牛中未检测到IgM。仅在FMDV“携带者”动物中，FMDV攻击引发了延长的双相分泌抗体反应。在黏膜分泌物和血清样本中均检测到该反应为FMDV特异性IgA，在攻击后5周时具有统计学意义（P<0.05）。这一观察结果可能是区分接种疫苗和/或康复恢复期牛与FMDV“携带者”的检测方法的基础。
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本文引用的文献
1
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J Comp Pathol. 1965 Apr;75:111-7. doi: 10.1016/0021-9975(65)90001-0.
2
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3
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5
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6
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8
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10
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J Virol Methods. 1994 Sep;49(2):179-86. doi: 10.1016/0166-0934(94)90042-6.
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