银屑病关节炎中的白细胞介素-6和可溶性白细胞介素-2受体：与临床和实验室参数的相关性
Interleukin-6 and soluble interleukin-2-receptor in psoriatic arthritis: correlations with clinical and laboratory parameters.
作者信息
Spadaro A, Taccari E, Riccieri V, Sensi F, Sili Scavalli A, Zoppini A
机构信息
Institute of Rheumatology. University La Sapienza Rome, Italy.
出版信息
Clin Exp Rheumatol. 1996 Jul-Aug;14(4):413-6.
OBJECTIVE
In this study we evaluated the relationships of IL-6 and sIL-2R levels with the main clinical and laboratory parameters in PsA patients with peripheral polyarthritis.
METHODS
Serum levels of IL-6 and sIL-2R were measured by an enzyme immunoassay kit in patients with peripheral (< 4 joints) PsA (n = 47), with RA (n = 41), or with psoriasis (N = 15) and in healthy volunteers (n = 15)
RESULTS
The patients with PsA had higher serum levels of IL-6 and sIL-2R than healthy volunteers and psoriatic patients, while they showed lower levels of IL-6 and sIL-2R than RA patients. We found abnormal values for IL-6 and sIL-2R in 63.8% and 57.4% of PsA patients, respectively. IL-6 levels correlated with the number of painful and swollen joints, RAI, physician's assessment, CRP and ESR, while sIL-2R levels correlated only with the number of swollen joints, the physician's assessment and ESR. IL-6 and sIL-2R correlated with each other.
CONCLUSION
Our study shows that IL-6 and sIL-2R may play a role in the pathogenetic mechanism of psoriatic arthritis.
目的
在本研究中，我们评估了外周多关节炎型银屑病关节炎（PsA）患者中白细胞介素-6（IL-6）和可溶性白细胞介素-2受体（sIL-2R）水平与主要临床及实验室参数之间的关系。
方法
采用酶免疫分析试剂盒检测外周关节受累少于4个的PsA患者（n = 47）、类风湿关节炎（RA）患者（n = 41）、银屑病患者（N = 15）及健康志愿者（n = 15）血清中IL-6和sIL-2R的水平。
结果
PsA患者血清中IL-6和sIL-2R水平高于健康志愿者和银屑病患者，但低于RA患者。我们发现分别有63.8%和57.4%的PsA患者IL-6和sIL-2R值异常。IL-6水平与疼痛和肿胀关节数量、类风湿关节炎疾病活动指数（RAI）、医生评估、C反应蛋白（CRP）及红细胞沉降率（ESR）相关，而sIL-2R水平仅与肿胀关节数量、医生评估及ESR相关。IL-6和sIL-2R相互之间存在相关性。
结论
我们的研究表明，IL-6和sIL-2R可能在银屑病关节炎的发病机制中起作用。
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