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特发性CD4⁺T淋巴细胞减少症中的淋巴细胞亚群多样性

Lymphocyte subset diversity in idiopathic CD4+ T lymphocytopenia.

作者信息

Tassinari P, Deibis L, Bianco N, Echeverría de Pérez G

机构信息

Instituto de Immunología, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.

出版信息

Clin Diagn Lab Immunol. 1996 Sep;3(5):611-3. doi: 10.1128/cdli.3.5.611-613.1996.

DOI:10.1128/cdli.3.5.611-613.1996
PMID:8877147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC170418/
Abstract

The clinical and public health importance of CD4+ T lymphocytopenia without human immunodeficiency virus infection is still unclear. We describe herein two new human immunodeficiency virus-negative patients with low numbers of peripheral CD4+ T cells and opportunistic infections (cerebral toxoplasmosis and tuberculosis plus extrapulmonary histoplasmosis). The low numbers of CD4+ CD29+ memory cells, the high percentage of gamma delta T-cell receptor cells, and the recovery of CD4+ cells after treatment were remarkable.

摘要

无人类免疫缺陷病毒感染的CD4 + T淋巴细胞减少症的临床和公共卫生重要性仍不清楚。我们在此描述了两名新的人类免疫缺陷病毒阴性患者，他们外周血CD4 + T细胞数量低且伴有机会性感染（脑弓形虫病、结核病加肺外组织胞浆菌病）。CD4 + CD29 + 记忆细胞数量低、γδT细胞受体细胞百分比高以及治疗后CD4 + 细胞的恢复情况显著。

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Idiopathic CD4+ T-lymphocytopenia--four patients with opportunistic infections and no evidence of HIV infection.特发性CD4+ T淋巴细胞减少症——4例机会性感染患者且无HIV感染证据。
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